The Relationship Between Chemotherapy Management and Quality of Life in Breast Cancer Patients in Yogyakarta
Main Article Content
Breast cancer, one of the most prevalent cancers in women, has a high mortality rate. Chemotherapy is commonly used to stop cancer growth, but it significantly affects patients' quality of life. While several studies have reported on the impact of adjuvant chemotherapy on the quality of life in breast cancer patients aged 20-80 with grades 1-4, limited research focuses on grade 2-3 patients aged 40-50, as measured by the QLQ C-30. Using random consecutive sampling, this study investigates the relationship between chemotherapy and quality of life in grade 2-3 breast cancer patients aged 40-50 in Yogyakarta. Quality of life is assessed through the QLQ C-30 questionnaire, with data analyzed by the unpaired t-test method at a 95% confidence level (p < 0.05). Results show a significant decrease in the overall quality of life (p = 0.000) but no significant differences in function (p = 0.152) and symptom scales (p = 0.15). Respondents not undergoing chemotherapy reported a better general quality of life than those receiving treatment.
Keywords:
Breast cancer, Chemotherapy, Quality of Life
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Chang, C.-H., Chen, S.-J., & Liu, C.-Y. (2015). Adjuvant treatments of breast cancer increase the risk of depressive disorders: A population-based study. Journal of Affective Disorders, 182, 44–49. https://doi.org/10.1016/j.jad.2015.04.027
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Hamood, R., Hamood, H., Merhasin, I., & Keinan-Boker, L. (2018). Chronic pain and other symptoms among breast cancer survivors: prevalence, predictors, and effects on quality of life. Breast Cancer Research and Treatment, 167, 157–169.
Lee, A. C., Driban, J. B., Price, L. L., Harvey, W. F., Rodday, A. M., & Wang, C. (2017). Responsiveness and Minimally Important Differences for 4 Patient-Reported Outcomes Measurement Information System Short Forms: Physical Function, Pain Interference, Depression, and Anxiety in Knee Osteoarthritis. The Journal of Pain, 18(9), 1096–1110. https://doi.org/10.1016/j.jpain.2017.05.001
Lee, S.-M., Kim, M., Lee, H. M., Kwon, K.-Y., & Koh, S.-B. (2015). Nonmotor symptoms in essential tremor: Comparison with Parkinson’s disease and normal control. Journal of the Neurological Sciences, 349(1–2), 168–173. https://doi.org/10.1016/j.jns.2015.01.012
Murphy, A. J., White, M., Viani, K., & Mosby, T. T. (2016). Evaluation of the nutrition screening tool for childhood cancer (SCAN). Clinical Nutrition, 35(1), 219–224. https://doi.org/10.1016/j.clnu.2015.02.009
Pérez-Herrero, E., & Fernández-Medarde, A. (2015). Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy. European Journal of Pharmaceutics and Biopharmaceutics, 93, 52–79. https://doi.org/10.1016/j.ejpb.2015.03.018
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Putri, A. R. C., Ladesvita, F., & Burmanajaya, B. (2024). Relationship between Lifestyle with Quality of Life in Breast Cancer Patients. Jurnal Berita Ilmu Keperawatan, 17(2), 170–179.
Sharma, N., & Purkayastha, A. (2017). Factors affecting quality of life in breast cancer patients: a descriptive and cross-sectional study with review of literature. Journal of Mid-Life Health, 8(2), 75–83.
Shrestha, A., Martin, C., Burton, M., Walters, S., Collins, K., & Wyld, L. (2019). Quality of life versus length of life considerations in cancer patients: a systematic literature review. Psycho?oncology, 28(7), 1367–1380.
Skevington, S. M., & Böhnke, J. R. (2018). How is subjective well-being related to quality of life? Do we need two concepts and both measures? Social Science & Medicine, 206, 22–30. https://doi.org/10.1016/j.socscimed.2018.04.005
Socha, M., & Sobiech, K. A. (2021). Socio-demographic and general health factors associated with quality of life in long-term breast cancer survivors from southwestern Poland. International Journal of Environmental Research and Public Health, 18(17), 9321.
Tan, M. L., Idris, D. B., Teo, L. W., Loh, S. Y., Seow, G. C., Chia, Y. Y., & Tin, A. S. (2014). Validation of EORTC QLQ-C30 and QLQ-BR23 questionnaires in the measurement of quality of life of breast cancer patients in Singapore. Asia-Pacific Journal of Oncology Nursing, 1(1), 22–32. https://doi.org/10.4103/2347-5625.135817
Trapani, D., Ginsburg, O., Fadelu, T., Lin, N. U., Hassett, M., Ilbawi, A. M., Anderson, B. O., & Curigliano, G. (2022). Global challenges and policy solutions in breast cancer control. Cancer Treatment Reviews, 104, 102339. https://doi.org/10.1016/j.ctrv.2022.102339
Verdugo, M. A., Gómez, L. E., Arias, B., Navas, P., & Schalock, R. L. (2014). Measuring quality of life in people with intellectual and multiple disabilities: Validation of the San Martín scale. Research in Developmental Disabilities, 35(1), 75–86. https://doi.org/10.1016/j.ridd.2013.10.025
Yang, Y., Peng, F., Wang, R., Guan, K., Jiang, T., Xu, G., Sun, J., & Chang, C. (2020). The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China. Journal of Autoimmunity, 109, 102434. https://doi.org/10.1016/j.jaut.2020.102434
