Hyperthyroidism is an endocrine disorder with the second-highest incidence rate after diabetes. Graves' disease is the most common cause of hyperthyroidism. Approximately 60% -80% of cases of hyperthyroidism are caused by Graves' disease, where women aged 20-50 are more dominant than men. Hyperthyroidism causes decreased heart rate and features an EKG pattern suggestive of sick sinus syndrome, including sinus bradycardia (heart rate <40 bpm), sinus pauses (sudden pauses in sinus nodes shorter than 2-3 seconds), and sinus arrest (sudden pauses in the sinus nodes). Sinus node longer than 2-3 seconds). This study aimed to determine the characteristics of patients with generalized anxiety disorder in hyperthyroidism accompanied by tonsillitis and thyroid eye disease with ECG features of sick sinus syndrome (SSS) in children and adults. This research uses the Systematic Review method using the preferred reporting items for systematic reviews and meta-analyses method, or PRISMA; this method is carried out systematically by following the correct research steps or protocols. Sources were taken from the PubMed site, and the Google Scholar site with journals published in 2017-2022 and then a screening was carried out to obtain 15,486 results. Based on the study's results, it was stated that journal clustering was carried out. The number of Scopus Q1 indexed journals was two journals, two journals Q2, and one journal indexed Sinta S1, so there were five extracted journals. It can be concluded that most journals discuss age and lifestyle related to the characteristics of the occurrence of panic disorders. The factors for hyperthyroidism are determined based on age and hyperthyroidism associated with panic disorders, an EKG picture of sick nodus dysfunction.