Toxic parents do not treat their children well and do not respect them as individuals. This is often done by parents who have mental disorders or are addicts, they can commit various types of violence on children, and even the child's mental health can be disrupted. Toxic parents are also unwilling to apologize or compromise and are irresponsible. This study aimed to determine the relationship between poisonous parents and mental health in children working at Karangampel Public Health Center. The method used in this study is field research with a quantitative correlational approach; this study's design is cross-sectional. The population studied was those who met the inclusion criteria, with a total of 25 children in the Karangampel Health Center Work Area. The sampling technique used is to use total sampling. The Karangampel Community Health Center working area has moderately toxic parents with normal mental health, namely one child (4.0%) and abnormal mental health with the same number of 1 child (4.0%), and respondents who have highly toxic parents with normal mental health have 0 children (0.0%) while those with abnormal mental health are 15 children (60.0%), while respondents with very high toxic parents with normal mental health are 0 children (0.0%) and eight children (32.0%). The results of statistical tests using the chi-square method for toxic parents with mental health in children showed a P value of 0.003 <0.05. The study results show a relationship between toxic parents and mental health in children in the Karangampel Health Center Working Area in 2022.