Analysis of Risk Factors for Comorbidities in Tuberculosis Patients and Resistance Patterns of Mycobacterium Tuberculosis at Gunung Jati Regional Hospital
Main Article Content
Tuberculosis (TB) treatment is complicated by drug resistance (especially MDR-TB) and comorbidities like diabetes, HIV, hypertension, kidney disease, cancer, lung diseases, psychiatric conditions, and malnutrition, all of which worsen outcomes and increase resistance risk. The purpose of the research was to find out and analyze the risk factors for tuberculosis patient comorbidities and the resistance pattern of Mycobacterium tuberculosis at the Gunung Jati Regional Hospital. The observational research method was analyzed with a crosssectional approach with univariate analysis, bivariate analysis (fisher's exact test) and multivariate analysis with logistic regression test with the backward method using medical record data of tuberculosis patients from January-November 2024 at the Gunung Jati Regional Hospital. The results of the comorbid results showed that the most tuberculosis patients were malnourished 75 (32.9%). The results of the characteristics of the most types of resistance were two drug combinations, namely INH and RIF Resistant, as many as 33 (14.5%). The results of fisher's exact test showed a significant relationship between DM and (p-value<0.001;OR= 4.42, 95% CI= 1.95-9.98) HIV (p-value=0.0.00;OR=4.19, 95% CI=1.67-10.5), kidney disease (p-value= <0.001;OR=4.81, 95% CI= 2.21-10.4), other lung diseases (p-value=0.015;OR= 2.52, 95% CI= 1.17-5.44), chronic hepatitis (p-value=0.005;OR= 2.86, 95% CI= 1.33-6.13), psychiatric conditions (p-value 0.004;OR=2.94, 95% CI= 1.37-6.32) and malnutrition (p-value=<0.001;OR= 5.35, 95% CI= 2.43-11.8) with Mycobacterium tuberculosis resistance. Conclusions: There is a significant association between DM, HIV, kidney disease, other lung diseases, chronic hepatitis, psychiatric conditions and malnutrition with Mycobacterium tuberculosis resistance patterns
Keywords:
tuberculosis, drug resistance, comorbidities
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Magassouba, A. S., Touré, A. A., Diallo, B. D., Camara, L. M., Touré, D., Conté, N., et al. (2021). Malnutrition prevalence and associated biochemical factors among drug-resistance tuberculosis (DR-TB) patients at key treatment sites in Conakry City, Republic of Guinea. Pan African Medical Journal, 38(1). https://doi.org/10.11604/pamj.2021.38.123.27261
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Ngouama, B. B., Djontu, J. C., Elion Assiana, D. O., Mouzinga, F. H., Dello, M. N. M., Abdul, J. B. P. A. A., et al. (2025). Drug-resistant tuberculosis profiles among patients presenting at the antituberculosis center of Brazzaville, Republic of Congo. Annals of Clinical Microbiology and Antimicrobials, 24(1). https://doi.org/10.1186/s12941-025-00677-4
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Rehman, A., Khattak, M., Mushtaq, U., Latif, M., Ahmad, I., Rasool, M. F., et al. (2023). The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: A systematic review and meta-analysis. Frontiers in Public Health, 11. https://doi.org/10.3389/fpubh.2023.1275690
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Samudra, G. R. S. A., Vidiari Juhanna, I., Wahyuni, N., & Dinata, I. M. K. (2024). Characteristics of pulmonary tuberculosis patients with multidrug-resistance at Dr. Kariadi Semarang Central Hospital in 2021–2022. Medicina, 55(1), 26–29. https://doi.org/10.15562/medicina.v55i1.1234
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Tobin, E. H., & Tristam, D. (2024). Tuberculosis. StatPearls Publishing. https://pubmed.ncbi.nlm.nih.gov/28722945/
Wahidah, I., Arwi, K. M., Norcahyanti, I., Rachmawati, E., Dewi, I. P., Aryani, D. E., & Machlaurin, A. (2024). Determinants of resistance patterns of multi-drug resistant tuberculosis (MDRTB) patients: A multi-center study in Jember, Indonesia. Indonesia Journal of Pharmacy Education, 4(1), 56–67.
Wang, C., Zou, R. Q., & He, G. Z. (2024a). Progress in mechanism-based diagnosis and treatment of tuberculosis comorbid with tumor. Frontiers in Immunology, 15, 1–11. https://doi.org/10.3389/fimmu.2024.1325282
Wang, R., Jin, L., Cui, H., Zhang, J., Zhang, X., Oyang, K., et al. (2024b). Comorbidities, drug-resistance and length of hospital stay among tuberculosis inpatients in Northeastern China: A retrospective observational study from 2013 to 2021. BMC Infectious Diseases, 24(1), 1–11. https://doi.org/10.1186/s12879-024-09001-3
World Health Organization. (2023). Global tuberculosis report 2023. WHO. https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2023
Zheng, J., Guo, M. H., Peng, H. W., Cai, X. L., Wu, Y. L., & Peng, X. E. (2020). The role of hepatitis B infection in anti-tuberculosis drug-induced liver injury: A meta-analysis of cohort studies. Epidemiology and Infection, 148, e54. https://doi.org/10.1017/S0950268820000412
