Effectiveness of Glycyrrhizinic Acid Compared to Trichloroacetic Acid in Condyloma Acuminata Treatment: A Literature Review
Main Article Content
Condyloma acuminata is genital benign neoplasm caused by HPV infection. Various treatment approach are developed to fulfill patient characteristic and preference. TCA is one of conventional method in condyloma acuminata treatment. Currently, glycyrrhizinic acid, a novel self-applied agent are exhibit promising results in condyloma acuminata treatment. This review aims to compare the effectiveness of Glycyrrhizinic acid and TCA in condyloma acuminata management. A systematic review was conducted following PRISMA guideline. Relevant articles published from 2005-2025 are identified from PubMed, Science Direct, and Google Scholar. Seven articles are included for qualitative review. Glycyrrhizinic acid and TCA has similiar efficacy in condyloma acuminata treatment. However, studies shows Glycyrrhizinic acid has antiviral and anti-inflammatory properties that help in removing warts while eliminating viral infection. It is also self-applied and has mild side effect. Thus, glycyrrhizinic acid are more superior for condyloma acuminata treatment, compared to TCA.
Keywords:
Glycyrrhizinic Acid, Trichloroacetic Acid, Efficacy, Condyloma Acuminata
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Sindhuja, T., Bhari, N., & Gupta, S. (2022). Asian guidelines for condyloma acuminatum. Journal of Infection and Chemotherapy, 28(7), 845–852.
Taner, Z. M., Taskiran, C., Onan, A. M., Gursoy, R., & Himmetoglu, O. (2007). Therapeutic value of trichloroacetic acid in the treatment of isolated genital warts on the external female genitalia. Journal of Reproductive Medicine, 52(6), 521–525.
Tsao, S., & Yin, M. (2015). Antioxidative and antiinflammatory activities of asiatic acid, glycyrrhizic acid, and oleanolic acid in human bronchial epithelial cells. Journal of Agricultural and Food Chemistry, 63(12), 3196–3204.
Valencia, M. H., Pacheco, A. C., Quijano, T. H., Girón, A. V, & López, C. V. (2011). Clinical response to glycyrrhizinic acid in genital infection due to human papillomavirus and low-grade squamous intraepithelial lesion. Clinical Practice, 1(4), e93. https://doi.org/10.4081/cp.2011.e93
Yenny, S. W., & Hidayah, R. (2013). Kondiloma Akuminata Pada Wanita Hamil: Salah Satu Modalitas Terapi. Jurnal Kesehatan Andalas, 2(1), 47–50.
Zelenkova, H. (2005). Preparations containing glycyrrhizic acid employed in dermatovenereologic practice. Conclusions of an international multicentre study. Dermatologia Kliniczna, 7(3).
Anggraini, I., Hoemardani, A. S., Nilasari, H., & Indriatmi, W. (2020). Randomised controlled trial of 1% and 5% 5-fluorouracil creams compared with 90% trichloroacetic acid solution for anogenital wart treatment. International Journal of STD & AIDS, 31(9), 849–858. https://doi.org/10.1177/0956462420925250
Bravo, V., Serrano, M., Duque, A., Ferragud, J., & Coronado, P. J. (2023). Glycyrrhizinic Acid as an Antiviral and Anticancer Agent in the Treatment of Human Papillomavirus. Journal of Personalized Medicine, 13(12), 1639. https://doi.org/10.3390/jpm13121639
Chauhan, S., Gulati, N., & Nagaich, U. (2018). Glycyrrhizic acid: extraction, screening and evaluation of anti-inflammatory property.
Csuk, R., Schwarz, S., Siewert, B., Kluge, R., & Ströhl, D. (2012). Conversions at C?30 of Glycyrrhetinic Acid and Their Impact on Antitumor Activity. Archiv Der Pharmazie, 345(3), 223–230.
Damayanti, N., & Susetiati, D. A. (2021). Complicating factors in the management of condyloma acuminata in HIV patients. Journal of Pakistan Association of Dermatologists, 31(4), 700–705.
Di?escu, D., Istrate-Ofi?eru, A. M., Ro?u, G. C., Iovan, L., Liliac, I. M., Zoril?, G. L., B?l??oiu, M., & Cercelaru, L. (2021). Clinical and pathological aspects of condyloma acuminatum - review of literature and case presentation. Romanian Journal of Morphology and Embryology, 62(2), 369–383. https://doi.org/10.47162/RJME.62.2.03
Domínguez Gómez, J., Simón, R. D., Abreu Daniel, A., & Zelenkova, H. (2012). Effectiveness of glycyrrhizinic Acid (glizigen) and an immunostimulant (viusid) to treat anogenital warts. ISRN Dermatology, 2012, 863692. https://doi.org/10.5402/2012/863692
Hirth, J. (2019). Disparities in HPV vaccination rates and HPV prevalence in the United States: a review of the literature. Human Vaccines & Immunotherapeutics, 15(1), 146–155.
Hutagalung, R. L. D., & Wiraguna, A. A. G. P. (2021). Kondiloma akuminata perianal pada seorang laki-laki biseksual disertai infeksi HIV stadium III yang diterapi dengan kombinasi asam trikloroasetat 80% dan seng oral. Intisari Sains Medis, 12(1), 76–82.
Kaçar, N., Ta?l?, L., Korkmaz, S., Ergin, ?., & Erdo?an, B. ?. (2012). Cantharidin–podophylotoxin–salicylic acid versus cryotherapy in the treatment of plantar warts: a randomized prospective study. Journal of the European Academy of Dermatology and Venereology, 26(7), 889–893.
Karaca, K., Aka, N., Köse, G., Kumru, P., & Sayharman, S. (2007). The Comparison Between Topical 5-Fluorouracil and Trichloroacetic Acid in The Treatment of External Genital Condyloma Accuminatum. Gynecology Obstetrics Reproductive Medicine. https://dergipark.org.tr/en/pub/goj
Lorduy, M. C. (2018). Use of trichloroacetic acid for management of oral lesions caused by human papillomavirus. General Dentistry, 66(2).
Lynde, C., Vender, R., Bourcier, M., & Bhatia, N. (2013). Clinical features of external genital warts. Journal of Cutaneous Medicine and Surgery, 17(6_suppl), S55–S60.
Mahajan, B. B. A., Tilak Raj, R. B., & Kumar, R. (2014). A comparative evaluation of therapeutic efficacy and safety of the cryotherapy (liquid nitrogen) with topical 20% podophyllin v/s intralesional bleomycin with topical 5% placentrex gel in the treatment of condyloma acuminata. Asian J Pharm Clin Res, 7(1), 36–42.
Özkaya, D. B., Erfan, G., & Ç?tamak, B. (2023). The Effectiveness of Genital Wart Treatments. Journal of Urological Surgery, 10(3), 179–188.
Recanati, M. A., Kramer, K. J., Maggio, J. J., & Chao, C. R. (2018). Cantharidin is Superior to Trichloroacetic Acid for the Treatment of Non-mucosal Genital Warts: A Pilot Randomized Controlled Trial. Clinical and Experimental Obstetrics & Gynecology, 45(3), 383–386. https://doi.org/10.12891/ceog4112.2018
Sindhuja, T., Bhari, N., & Gupta, S. (2022). Asian guidelines for condyloma acuminatum. Journal of Infection and Chemotherapy, 28(7), 845–852.
Taner, Z. M., Taskiran, C., Onan, A. M., Gursoy, R., & Himmetoglu, O. (2007). Therapeutic value of trichloroacetic acid in the treatment of isolated genital warts on the external female genitalia. Journal of Reproductive Medicine, 52(6), 521–525.
Tsao, S., & Yin, M. (2015). Antioxidative and antiinflammatory activities of asiatic acid, glycyrrhizic acid, and oleanolic acid in human bronchial epithelial cells. Journal of Agricultural and Food Chemistry, 63(12), 3196–3204.
Valencia, M. H., Pacheco, A. C., Quijano, T. H., Girón, A. V, & López, C. V. (2011). Clinical response to glycyrrhizinic acid in genital infection due to human papillomavirus and low-grade squamous intraepithelial lesion. Clinical Practice, 1(4), e93. https://doi.org/10.4081/cp.2011.e93
Yenny, S. W., & Hidayah, R. (2013). Kondiloma Akuminata Pada Wanita Hamil: Salah Satu Modalitas Terapi. Jurnal Kesehatan Andalas, 2(1), 47–50.
Zelenkova, H. (2005). Preparations containing glycyrrhizic acid employed in dermatovenereologic practice. Conclusions of an international multicentre study. Dermatologia Kliniczna, 7(3).
