Effectiveness of Platelet-Rich Plasma on Improve Clinical Outcomes After Knee Arthroscopy: A Systematic Review
Main Article Content
This systematic review aims to evaluate the effectiveness of Platelet-Rich Plasma (PRP) in improving postoperative outcomes in knee arthroscopy. The review was conducted following PRISMA guidelines, with studies published between 2020 and 2024 sourced from Scopus, PubMed, and Crossref databases. Keywords such as "platelet-rich plasma," "PRP," and "knee arthroscopy" were used to identify relevant articles. After applying inclusion and exclusion criteria, 10 studies were selected. The review synthesized data on study objectives, PRP protocols, and clinical outcomes. Results showed that PRP significantly improved postoperative recovery compared to traditional treatments like hyaluronic acid, with patients experiencing reduced pain and better functional outcomes, as measured by the KOOS and IKDC scores. PRP also demonstrated potential for cartilage regeneration, especially when used alongside mesenchymal stem cells. However, variations in PRP preparation methods and patient selection impacted the outcomes. The findings suggest that PRP is a promising adjunctive therapy in knee arthroscopy, offering enhanced clinical outcomes due to its regenerative and anti-inflammatory properties. Standardization of PRP preparation protocols and further long-term studies are needed to optimize its clinical application.
Keywords:
joint function, knee arthroscopy, platelet-rich plasma, pain reduction, tissue regeneration
A Single-Blinded Randomized Controlled Trial of Mesenchymal Stem Cell Therapy for the Treatment of Osteoarthritis of the Knee with Active Control. (2021). Journal of Stem Cells and Regenerative Medicine, 17(1). https://doi.org/10.46582/jsrm.1701002
Belk, J. W., Kraeutler, M. J., Houck, D. A., Goodrich, J. A., Dragoo, J. L., & McCarty, E. C. (2021). Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials. The American Journal of Sports Medicine, 49(1), 249–260. https://doi.org/10.1177/0363546520909397
Dhall, Dr. A., Agrawal, Dr. S., Thukral, Dr. B., & Swarup, Dr. A. (2021). MRI evaluation of knee trauma and its correlation with clinical examination and arthroscopic findings. International Journal of Radiology and Diagnostic Imaging, 4(1), 84–87. https://doi.org/10.33545/26644436.2021.v4.i1b.166
Dulic, O., Rasovic, P., Lalic, I., Kecojevic, V., Gavrilovic, G., Abazovic, D., Maric, D., Miskulin, M., & Bumbasirevic, M. (2021). Bone Marrow Aspirate Concentrate versus Platelet Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis. Medicina, 57(11), 1193. https://doi.org/10.3390/medicina57111193
Flury, G. (2023). Pathophysiology of Arthrofibrosis of the Knee after Ligamentous Injury and Repair: Synthesizing Past and Current Knowledge for Personalized Prevention. https://doi.org/10.31219/osf.io/bc3sz
Giorgini, A., Selleri, F., Zambianchi, F., Cataldo, G., Francioni, E., & Catani, F. (2022a). Autologous Micro-Fragmented Adipose Tissue Associated With Arthroscopy in Moderate–severe Knee Osteoarthritis: Outcome at Two Year Follow-Up. 23(1). https://doi.org/10.1186/s12891-022-05921-6
Giorgini, A., Selleri, F., Zambianchi, F., Cataldo, G., Francioni, E., & Catani, F. (2022b). Autologous micro-fragmented adipose tissue associated with arthroscopy in moderate–severe knee osteoarthritis: outcome at two year follow-up. BMC Musculoskeletal Disorders, 23(1), 963. https://doi.org/10.1186/s12891-022-05921-6
Gorbatenko, A. I., Kostyanaya, N. O., Malanin, D. A., Sikilinda, V. D., Demeshchenko, M. V., Suchilin, I. A., & Kondrashenko, V. V. (2022). Using orthobiologics products in knee osteoarthritis. Saratov Medical Journal, 3(4). https://doi.org/10.15275/sarmj.2022.0404
Gyawali, B., Joshi, A., & Kayastha, N. (2020). Knee injuries: correlation of MRI with arthroscopic findings. Journal of Patan Academy of Health Sciences, 7(3), 35–40. https://doi.org/10.3126/jpahs.v7i3.33822
Hughes, P. E. (2023). The Effects of Autologous Stem Cells from Bone Marrow and Adipose Tissue on Patients with Knee Osteoarthritis. Journal Of Regenerative Biology And Medicine. https://doi.org/10.37191/Mapsci-2582-385X-5(4)-135
Jurin, M. A., Nenad, V., Joško, S., Matija, M., Miljenko, N., & Petra, M. J. (2020). Acute abdomen as complication of a knee arthroscopy: A case report. Archives of Surgery and Clinical Research, 4(2), 051–053. https://doi.org/10.29328/journal.ascr.1001054
Khoury, M. A., Chamari, K., Tabben, M., Alkhelaifi, K., Papacostas, E., Marín Fermín, T., Laupheimer, M., & D?Hooghe, P. (2023a). Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma. 14(4), 433–444. https://doi.org/10.1177/19476035231166127
Khoury, M. A., Chamari, K., Tabben, M., Alkhelaifi, K., Papacostas, E., Marín Fermín, T., Laupheimer, M., & D?Hooghe, P. (2023b). Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma. CARTILAGE, 14(4), 433–444. https://doi.org/10.1177/19476035231166127
Leung, S., Khan, A., Arias, A., & Hughes, P. E. (2023). The Effects of Autologous Stem Cells From Bone Marrow and Adipose Tissue on Patients With Knee Osteoarthritis. https://doi.org/10.37191/mapsci-2582-385x-5(4)-135
Lewis, E., Merghani, K., Robertson, I., Mulford, J., Prentice, B., Mathew, R., Van Winden, P., & Ogden, K. (2022). The effectiveness of leucocyte-poor platelet-rich plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial. The Bone & Joint Journal, 104-B(6), 663–671. https://doi.org/10.1302/0301-620X.104B6.BJJ-2021-1109.R2
Liang, W., Zhou, C., Bai, J., Zhang, H., Jiang, B., Wang, J., Fu, L., Long, H., Huang, X., Zhao, J., & Zhu, H. (2024). Current advancements in therapeutic approaches in orthopedic surgery: a review of recent trends. Frontiers in Bioengineering and Biotechnology, 12. https://doi.org/10.3389/fbioe.2024.1328997
Liang, Y., Li, J., Wang, Y., He, J., Chen, L., Chu, J., & Wu, H. (2022). Platelet Rich Plasma in the Repair of Articular Cartilage Injury: A Narrative Review. CARTILAGE, 13(3), 194760352211184. https://doi.org/10.1177/19476035221118419
Medina-Porqueres, I., Martin-Garcia, P., Sanz-De-Diego, S., Gomez-Caceres, A., Moya-Torrecilla, F., Reyes-Eldblom, M., & Rosado-Velazquez, D. (2022a). Clinical and Functional Outcome of Meniscal Injuries Treated With Platelet-Rich Plasma: A Single-Center Case Series. 19(12), 7118. https://doi.org/10.3390/ijerph19127118
Medina-Porqueres, I., Martin-Garcia, P., Sanz-De-Diego, S., Gomez-Caceres, A., Moya-Torrecilla, F., Reyes-Eldblom, M., & Rosado-Velazquez, D. (2022b). Clinical and Functional Outcome of Meniscal Injuries Treated with Platelet-Rich Plasma: A Single-Center Case Series. International Journal of Environmental Research and Public Health, 19(12), 7118. https://doi.org/10.3390/ijerph19127118
Oganesyan, R., Klemt, C., Esposito, J., Tirumala, V., Xiong, L., & Kwon, Y.-M. (2022). Knee Arthroscopy Prior to Revision TKA Is Associated with Increased Re-Revision for Stiffness. The Journal of Knee Surgery, 35(11), 1223–1228. https://doi.org/10.1055/s-0040-1722662
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., & Brennan, S. E. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Bmj, 372.
Patel, S., Kumar, V., Kumar, R., Sharma, S., Sharma, R., Kaur, R., & Kumar, P. (2022). Trends of the publications of platelet-rich plasma use in osteoarthritis knee – A PubMed and Scopus bibliometric analysis. Journal of Arthroscopic Surgery and Sports Medicine, 3, 101. https://doi.org/10.25259/JASSM_34_2021
Ruane, J. J., Ross, A., Zigmont, V., McClure, D., & Gascon, G. (2021). A Single-Blinded Randomized Controlled Trial of Mesenchymal Stem Cell Therapy for the Treatment of Osteoarthritis of the Knee With Active Control. 17(1). https://doi.org/10.46582/jsrm.1701002
Sax, O. C., Bains, S. S., Chen, Z., Salib, C. G., Nace, J., & Delanois, R. E. (2022). Knee Arthroscopy Prior to Total Knee Arthroplasty: Temporal Relationship to Surgical Complications. The Journal of Knee Surgery, 35(14), 1504–1510. https://doi.org/10.1055/s-0042-1757595
Screpis, D., Natali, S., Piovan, G., Iacono, V., Magnanelli, S., Farinelli, L., & Zorzi, C. (2021a). Autologous Platelet-Rich Fibrin Matrix–Augmented Repair for Parameniscal Cysts: Surgical Technique. 10(10), e2287–e2292. https://doi.org/10.1016/j.eats.2021.07.005
Screpis, D., Natali, S., Piovan, G., Iacono, V., Magnanelli, S., Farinelli, L., & Zorzi, C. (2021b). Autologous Platelet-Rich Fibrin Matrix–Augmented Repair for Parameniscal Cysts: Surgical Technique. Arthroscopy Techniques, 10(10), e2287–e2292. https://doi.org/10.1016/j.eats.2021.07.005
Sdeek, M., Sabry, D., El-Sdeek, H., & Darweash, A. (2021). Intra-articular injection of Platelet rich plasma versus Hyaluronic acid for moderate knee osteoarthritis. A prospective, double-blind randomized controlled trial on 189 patients with follow-up for three years. Acta Orthopaedica Belgica, 87(4), 729–734. https://doi.org/10.52628/87.4.18
Sherman, W. F., Verzeaux, N. P., Freiberger, C., Lee, O. C., Wilder, J. H., Flick, T. R., & Heard, W. M. R. (2022). Local and Systemic Complications of Knee and Hip Arthroscopy: A Matched-Cohort Study. Orthopaedic Journal of Sports Medicine, 10(11). https://doi.org/10.1177/23259671221131059
Singh, Dr. D., Manikandarajan, Dr., & Dinesh, Dr. C. (2020). Effectiveness of platelet-rich plasma (PRP) in the treatment of mild to moderate knee osteoarthritis. International Journal of Orthopaedics Sciences, 6(4), 08–13. https://doi.org/10.22271/ortho.2020.v6.i4a.2310
Singh, N., Trivedi, V., Kumar, V., Mishra, N., Ahmad, S., Ayar, S., Kataria, S., & Kharbanda, H. (2022). A Comparative Study of Osteoarthritis Knee Arthroscopy Versus Intra-Articular Platelet Rich Plasma Injection: A Randomised Study. 16(2), 31–40. https://doi.org/10.5704/moj.2207.004
St?pie?, K., Kosterna, K., & Babiak, I. (2022). Infection complicating 794 primary and revision arthroscopies. Accuracy of actual prophylactic procedures against infection and results from a single orthopedic center in Poland. Post?py Higieny i Medycyny Do?wiadczalnej, 76(1), 351–357. https://doi.org/10.2478/ahem-2022-0026
Tirtosuharto, H., Wiratnaya, I. G. E., & Astawa, P. (2022a). Adjunctive Platelet-Rich Plasma and Hyaluronic Acid Injection After Arthroscopic Debridement in Kellgren-Lawrence Grade 3 and 4 Knee Osteoarthritis. 13(10), 911–920. https://doi.org/10.5312/wjo.v13.i10.911
Tirtosuharto, H., Wiratnaya, I. G. E., & Astawa, P. (2022b). Adjunctive platelet-rich plasma and hyaluronic acid injection after arthroscopic debridement in Kellgren-Lawrence grade 3 and 4 knee osteoarthritis. World Journal of Orthopedics, 13(10), 911–920. https://doi.org/10.5312/wjo.v13.i10.911
van der Burgt, J. M. A., Camps, S. M., Antico, M., Carneiro, G., & Fontanarosa, D. (2021). Arthroscope Localization in 3D Ultrasound Volumes Using Weakly Supervised Deep Learning. Applied Sciences, 11(15), 6828. https://doi.org/10.3390/app11156828
Venosa, M., Calafiore, F., Mazzoleni, M., Romanini, E., Cerciello, S., & Calvisi, V. (2022a). Platelet-Rich Plasma and Adipose-Derived Mesenchymal Stem Cells in Association With Arthroscopic Microfracture of Knee Articular Cartilage Defects: A Pilot Randomized Controlled Trial. 2022, 1–9. https://doi.org/10.1155/2022/6048477
Venosa, M., Calafiore, F., Mazzoleni, M., Romanini, E., Cerciello, S., & Calvisi, V. (2022b). Platelet-Rich Plasma and Adipose-Derived Mesenchymal Stem Cells in Association with Arthroscopic Microfracture of Knee Articular Cartilage Defects: A Pilot Randomized Controlled Trial. Advances in Orthopedics, 2022, 1–9. https://doi.org/10.1155/2022/6048477
Zheng, W., Li, H., Hu, K., Li, L., & Bei, M. (2021a). Chondromalacia Patellae: Current Options and Emerging Cell Therapies. 12(1). https://doi.org/10.1186/s13287-021-02478-4
Zheng, W., Li, H., Hu, K., Li, L., & Bei, M. (2021b). Chondromalacia patellae: current options and emerging cell therapies. Stem Cell Research & Therapy, 12(1), 412. https://doi.org/10.1186/s13287-021-02478-4
Belk, J. W., Kraeutler, M. J., Houck, D. A., Goodrich, J. A., Dragoo, J. L., & McCarty, E. C. (2021). Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials. The American Journal of Sports Medicine, 49(1), 249–260. https://doi.org/10.1177/0363546520909397
Dhall, Dr. A., Agrawal, Dr. S., Thukral, Dr. B., & Swarup, Dr. A. (2021). MRI evaluation of knee trauma and its correlation with clinical examination and arthroscopic findings. International Journal of Radiology and Diagnostic Imaging, 4(1), 84–87. https://doi.org/10.33545/26644436.2021.v4.i1b.166
Dulic, O., Rasovic, P., Lalic, I., Kecojevic, V., Gavrilovic, G., Abazovic, D., Maric, D., Miskulin, M., & Bumbasirevic, M. (2021). Bone Marrow Aspirate Concentrate versus Platelet Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis. Medicina, 57(11), 1193. https://doi.org/10.3390/medicina57111193
Flury, G. (2023). Pathophysiology of Arthrofibrosis of the Knee after Ligamentous Injury and Repair: Synthesizing Past and Current Knowledge for Personalized Prevention. https://doi.org/10.31219/osf.io/bc3sz
Giorgini, A., Selleri, F., Zambianchi, F., Cataldo, G., Francioni, E., & Catani, F. (2022a). Autologous Micro-Fragmented Adipose Tissue Associated With Arthroscopy in Moderate–severe Knee Osteoarthritis: Outcome at Two Year Follow-Up. 23(1). https://doi.org/10.1186/s12891-022-05921-6
Giorgini, A., Selleri, F., Zambianchi, F., Cataldo, G., Francioni, E., & Catani, F. (2022b). Autologous micro-fragmented adipose tissue associated with arthroscopy in moderate–severe knee osteoarthritis: outcome at two year follow-up. BMC Musculoskeletal Disorders, 23(1), 963. https://doi.org/10.1186/s12891-022-05921-6
Gorbatenko, A. I., Kostyanaya, N. O., Malanin, D. A., Sikilinda, V. D., Demeshchenko, M. V., Suchilin, I. A., & Kondrashenko, V. V. (2022). Using orthobiologics products in knee osteoarthritis. Saratov Medical Journal, 3(4). https://doi.org/10.15275/sarmj.2022.0404
Gyawali, B., Joshi, A., & Kayastha, N. (2020). Knee injuries: correlation of MRI with arthroscopic findings. Journal of Patan Academy of Health Sciences, 7(3), 35–40. https://doi.org/10.3126/jpahs.v7i3.33822
Hughes, P. E. (2023). The Effects of Autologous Stem Cells from Bone Marrow and Adipose Tissue on Patients with Knee Osteoarthritis. Journal Of Regenerative Biology And Medicine. https://doi.org/10.37191/Mapsci-2582-385X-5(4)-135
Jurin, M. A., Nenad, V., Joško, S., Matija, M., Miljenko, N., & Petra, M. J. (2020). Acute abdomen as complication of a knee arthroscopy: A case report. Archives of Surgery and Clinical Research, 4(2), 051–053. https://doi.org/10.29328/journal.ascr.1001054
Khoury, M. A., Chamari, K., Tabben, M., Alkhelaifi, K., Papacostas, E., Marín Fermín, T., Laupheimer, M., & D?Hooghe, P. (2023a). Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma. 14(4), 433–444. https://doi.org/10.1177/19476035231166127
Khoury, M. A., Chamari, K., Tabben, M., Alkhelaifi, K., Papacostas, E., Marín Fermín, T., Laupheimer, M., & D?Hooghe, P. (2023b). Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma. CARTILAGE, 14(4), 433–444. https://doi.org/10.1177/19476035231166127
Leung, S., Khan, A., Arias, A., & Hughes, P. E. (2023). The Effects of Autologous Stem Cells From Bone Marrow and Adipose Tissue on Patients With Knee Osteoarthritis. https://doi.org/10.37191/mapsci-2582-385x-5(4)-135
Lewis, E., Merghani, K., Robertson, I., Mulford, J., Prentice, B., Mathew, R., Van Winden, P., & Ogden, K. (2022). The effectiveness of leucocyte-poor platelet-rich plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial. The Bone & Joint Journal, 104-B(6), 663–671. https://doi.org/10.1302/0301-620X.104B6.BJJ-2021-1109.R2
Liang, W., Zhou, C., Bai, J., Zhang, H., Jiang, B., Wang, J., Fu, L., Long, H., Huang, X., Zhao, J., & Zhu, H. (2024). Current advancements in therapeutic approaches in orthopedic surgery: a review of recent trends. Frontiers in Bioengineering and Biotechnology, 12. https://doi.org/10.3389/fbioe.2024.1328997
Liang, Y., Li, J., Wang, Y., He, J., Chen, L., Chu, J., & Wu, H. (2022). Platelet Rich Plasma in the Repair of Articular Cartilage Injury: A Narrative Review. CARTILAGE, 13(3), 194760352211184. https://doi.org/10.1177/19476035221118419
Medina-Porqueres, I., Martin-Garcia, P., Sanz-De-Diego, S., Gomez-Caceres, A., Moya-Torrecilla, F., Reyes-Eldblom, M., & Rosado-Velazquez, D. (2022a). Clinical and Functional Outcome of Meniscal Injuries Treated With Platelet-Rich Plasma: A Single-Center Case Series. 19(12), 7118. https://doi.org/10.3390/ijerph19127118
Medina-Porqueres, I., Martin-Garcia, P., Sanz-De-Diego, S., Gomez-Caceres, A., Moya-Torrecilla, F., Reyes-Eldblom, M., & Rosado-Velazquez, D. (2022b). Clinical and Functional Outcome of Meniscal Injuries Treated with Platelet-Rich Plasma: A Single-Center Case Series. International Journal of Environmental Research and Public Health, 19(12), 7118. https://doi.org/10.3390/ijerph19127118
Oganesyan, R., Klemt, C., Esposito, J., Tirumala, V., Xiong, L., & Kwon, Y.-M. (2022). Knee Arthroscopy Prior to Revision TKA Is Associated with Increased Re-Revision for Stiffness. The Journal of Knee Surgery, 35(11), 1223–1228. https://doi.org/10.1055/s-0040-1722662
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., & Brennan, S. E. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Bmj, 372.
Patel, S., Kumar, V., Kumar, R., Sharma, S., Sharma, R., Kaur, R., & Kumar, P. (2022). Trends of the publications of platelet-rich plasma use in osteoarthritis knee – A PubMed and Scopus bibliometric analysis. Journal of Arthroscopic Surgery and Sports Medicine, 3, 101. https://doi.org/10.25259/JASSM_34_2021
Ruane, J. J., Ross, A., Zigmont, V., McClure, D., & Gascon, G. (2021). A Single-Blinded Randomized Controlled Trial of Mesenchymal Stem Cell Therapy for the Treatment of Osteoarthritis of the Knee With Active Control. 17(1). https://doi.org/10.46582/jsrm.1701002
Sax, O. C., Bains, S. S., Chen, Z., Salib, C. G., Nace, J., & Delanois, R. E. (2022). Knee Arthroscopy Prior to Total Knee Arthroplasty: Temporal Relationship to Surgical Complications. The Journal of Knee Surgery, 35(14), 1504–1510. https://doi.org/10.1055/s-0042-1757595
Screpis, D., Natali, S., Piovan, G., Iacono, V., Magnanelli, S., Farinelli, L., & Zorzi, C. (2021a). Autologous Platelet-Rich Fibrin Matrix–Augmented Repair for Parameniscal Cysts: Surgical Technique. 10(10), e2287–e2292. https://doi.org/10.1016/j.eats.2021.07.005
Screpis, D., Natali, S., Piovan, G., Iacono, V., Magnanelli, S., Farinelli, L., & Zorzi, C. (2021b). Autologous Platelet-Rich Fibrin Matrix–Augmented Repair for Parameniscal Cysts: Surgical Technique. Arthroscopy Techniques, 10(10), e2287–e2292. https://doi.org/10.1016/j.eats.2021.07.005
Sdeek, M., Sabry, D., El-Sdeek, H., & Darweash, A. (2021). Intra-articular injection of Platelet rich plasma versus Hyaluronic acid for moderate knee osteoarthritis. A prospective, double-blind randomized controlled trial on 189 patients with follow-up for three years. Acta Orthopaedica Belgica, 87(4), 729–734. https://doi.org/10.52628/87.4.18
Sherman, W. F., Verzeaux, N. P., Freiberger, C., Lee, O. C., Wilder, J. H., Flick, T. R., & Heard, W. M. R. (2022). Local and Systemic Complications of Knee and Hip Arthroscopy: A Matched-Cohort Study. Orthopaedic Journal of Sports Medicine, 10(11). https://doi.org/10.1177/23259671221131059
Singh, Dr. D., Manikandarajan, Dr., & Dinesh, Dr. C. (2020). Effectiveness of platelet-rich plasma (PRP) in the treatment of mild to moderate knee osteoarthritis. International Journal of Orthopaedics Sciences, 6(4), 08–13. https://doi.org/10.22271/ortho.2020.v6.i4a.2310
Singh, N., Trivedi, V., Kumar, V., Mishra, N., Ahmad, S., Ayar, S., Kataria, S., & Kharbanda, H. (2022). A Comparative Study of Osteoarthritis Knee Arthroscopy Versus Intra-Articular Platelet Rich Plasma Injection: A Randomised Study. 16(2), 31–40. https://doi.org/10.5704/moj.2207.004
St?pie?, K., Kosterna, K., & Babiak, I. (2022). Infection complicating 794 primary and revision arthroscopies. Accuracy of actual prophylactic procedures against infection and results from a single orthopedic center in Poland. Post?py Higieny i Medycyny Do?wiadczalnej, 76(1), 351–357. https://doi.org/10.2478/ahem-2022-0026
Tirtosuharto, H., Wiratnaya, I. G. E., & Astawa, P. (2022a). Adjunctive Platelet-Rich Plasma and Hyaluronic Acid Injection After Arthroscopic Debridement in Kellgren-Lawrence Grade 3 and 4 Knee Osteoarthritis. 13(10), 911–920. https://doi.org/10.5312/wjo.v13.i10.911
Tirtosuharto, H., Wiratnaya, I. G. E., & Astawa, P. (2022b). Adjunctive platelet-rich plasma and hyaluronic acid injection after arthroscopic debridement in Kellgren-Lawrence grade 3 and 4 knee osteoarthritis. World Journal of Orthopedics, 13(10), 911–920. https://doi.org/10.5312/wjo.v13.i10.911
van der Burgt, J. M. A., Camps, S. M., Antico, M., Carneiro, G., & Fontanarosa, D. (2021). Arthroscope Localization in 3D Ultrasound Volumes Using Weakly Supervised Deep Learning. Applied Sciences, 11(15), 6828. https://doi.org/10.3390/app11156828
Venosa, M., Calafiore, F., Mazzoleni, M., Romanini, E., Cerciello, S., & Calvisi, V. (2022a). Platelet-Rich Plasma and Adipose-Derived Mesenchymal Stem Cells in Association With Arthroscopic Microfracture of Knee Articular Cartilage Defects: A Pilot Randomized Controlled Trial. 2022, 1–9. https://doi.org/10.1155/2022/6048477
Venosa, M., Calafiore, F., Mazzoleni, M., Romanini, E., Cerciello, S., & Calvisi, V. (2022b). Platelet-Rich Plasma and Adipose-Derived Mesenchymal Stem Cells in Association with Arthroscopic Microfracture of Knee Articular Cartilage Defects: A Pilot Randomized Controlled Trial. Advances in Orthopedics, 2022, 1–9. https://doi.org/10.1155/2022/6048477
Zheng, W., Li, H., Hu, K., Li, L., & Bei, M. (2021a). Chondromalacia Patellae: Current Options and Emerging Cell Therapies. 12(1). https://doi.org/10.1186/s13287-021-02478-4
Zheng, W., Li, H., Hu, K., Li, L., & Bei, M. (2021b). Chondromalacia patellae: current options and emerging cell therapies. Stem Cell Research & Therapy, 12(1), 412. https://doi.org/10.1186/s13287-021-02478-4
