Correlation Between Serum Iron with Platelet Count in Patients with End Stage Renal Disease (Esrd) on Hemodialysis at Gunung Jati Cirebon Hospital
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Chronic Kidney Disease (CKD) is a kidney disorder that occurs gradually and irreversibly, characterized by structural abnormalities or abnormalities in kidney function lasts more than 3 months. CKD stage 5 (also known as ESRD) requires hemodialysis. ESRD on hemodialysis patients are often have iron deficiency. Serum iron levels may reflect changes in platelet counts, but correlation between them is still unclear. To determine the correlation between serum iron with platelet count in patients with ESRD on hemodialysis at Gunung Jati Cirebon Hospital. This is an observational research with a cross-sectional design and retrospective approach. Medical records containing serum iron level and platelet count from January to July 2024 were studied, with a maximum interval of 10 days between each test. Total of 55 samples were obtained. The data were analized using spearman's rho test. In this research, there were 37 (67,72%) patients were iron deficiency and 18 (32,73%) with a normal iron serum. The research also shown that 3 (5,45%) patients had thrombocytopenia, 47 (85,45%) patients had normal platelet count, and 5 (9,10%) had thrombocytosis. Spearman’s rho analysis were done resulting a p-value of 0,045 (p<0,05) and rho -0,271 (0,20-0,39). There was a significant correlation with negative affiliation between serum iron and platelet count in ESRD on hemodialysis patients at Gunung Jati Cirebon Hospital. The implication of this research is that low serum iron levels in ESRD patients undergoing hemodialysis can contribute to changes in platelet count, with a significant negative correlation.
Baaten, C. C., Sternkopf, M., Henning, T., Marx, N., Jankowski, J., & Noels, H. (2021). Platelet function in CKD: a systematic review and meta-analysis. Journal of the American Society of Nephrology, 32(7), 1583–1598.
Chiu, P.-C., Chattopadhyay, A., Wu, M.-C., Hsiao, T.-H., Lin, C.-H., & Lu, T.-P. (2021). Elucidation of a causal relationship between platelet count and hypertension: a Bi-directional mendelian randomization research. Frontiers in Cardiovascular Medicine, 8, 743075.
Cole, R. (2024). Inter-rater reliability methods in qualitative case research research. Sociological Methods & Research, 53(4), 1944–1975.
Fishbane, S., & Spinowitz, B. (2018). Update on Anemia in ESRD and Earlier Stages of CKD: Core Curriculum 2018. American Journal of Kidney Diseases, 71(3), 423–435. https://doi.org/10.1053/j.ajkd.2017.09.026
Kim, S., Molnar, M. Z., Fonarow, G. C., Streja, E., Wang, J., Gillen, D. L., Mehrotra, R., Brunelli, S. M., Kovesdy, C. P., Kalantar-Zadeh, K., & Rhee, C. M. (2016). Mean platelet volume and mortality risk in a national incident hemodialysis cohort. International Journal of Cardiology, 220, 862–870. https://doi.org/10.1016/j.ijcard.2016.06.074
Liao, R., Zhou, X., Ma, D., Tang, J., & Zhong, H. (2022). Iron Deficiency is Associated With Platelet Count Elevation in Patients With Dialysis-dependent Chronic Kidney Disease. Journal of Renal Nutrition, 32(5), 587–594. https://doi.org/10.1053/j.jrn.2021.09.004
OB, L., Elwerfally, H. H., Sheriff, D. S., & Younis, M. Y. G. (n.d.). Haematological Changes in Predialyzed and Hemodialyzed Chronic Kidney Disease patients in Libya.
Patel, G. R., & Prajapati, G. R. (2022). Platelet count in adults with iron deficiency anemia and its correlation with serum iron parameters: An observational research at a tertiary care center in northwestern India. Scholars Journal of Applied Medical Sciences, 10(6), 910–916.
Prasetyorini, T., Lestari, D., & Lesmana, K. (2024). Perbandingan Kadar Fe Serum, TIBC dan Ferritin Pada Pasien Gagal Ginjal Kronik Pre dan Post Hemodialisa di RSUD Leuwiliang: Comparison of Serum Fe, TIBC and Ferritin Levels in Failed Patients Chronic Kidney Pre and Post Hemodialysis at SRUD Leuwiliang. Borneo Journal of Medical Laboratory Technology, 6(2), 584–591.
Suliman, N. A., Awadalla, K. E., Bakheit, K. H., & Mohamed, A. O. (2023). Cancer antigen 125 and C-reactive protein inflammatory mediators and uric acid in association with preeclampsia in North Kordofan State, Western Sudan. Plos One, 18(1), e0280256.
Thakar, S., Gabarin, N., Gupta, A., Radford, M., Warkentin, T. E., & Arnold, D. M. (2021). Anemia-Induced Bleeding in Patients with Platelet Disorders. Transfusion Medicine Reviews, 35(3), 22–28. https://doi.org/10.1016/j.tmrv.2021.06.001
Vaseekaran, S. K. (2023). Wcn23-0879 Research Of The Correlation Of Hepcidin And Reticulocyte Hemoglobin Equivalent In Absolute And Functional Iron Deficiency Anemia In Ckd Patients. Kidney International Reports, 8(3), S155. https://doi.org/10.1016/j.ekir.2023.02.349
Vashistha, T., Streja, E., Molnar, M. Z., Rhee, C. M., Moradi, H., Soohoo, M., Kovesdy, C. P., & Kalantar-Zadeh, K. (2016). Red Cell Distribution Width and Mortality in Hemodialysis Patients. American Journal of Kidney Diseases, 68(1), 110–121. https://doi.org/10.1053/j.ajkd.2015.11.020
Voudoukis, E., Vetsika, E.-K., Giannakopoulou, K., Karmiris, K., Theodoropoulou, A., Sfiridaki, A., Georgoulias, V., Paspatis, G. A., & Koutroubakis, I. E. (2016). Distinct features of circulating microparticles and their relationship with disease activity in inflammatory bowel disease. Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology, 29(2), 180.
