Radiotherapy technique is a systematic radiation planning method or procedure used for cancer treatment in the field of radiotherapy. Modern radiotherapy techniques allow the delivery of high doses at target volumes without dose escalation to at-risk organs, offering the possibility of better local control while maintaining a good quality of life. This study aims to analyze the difference in Treatment Planning System (TPS) results between Intensity Modulation Radiation Therapy (IMRT) and Volumetric Modulation Arc Therapy (VMAT) techniques in irradiation of brain tumors with Glioblastoma cases based on the dose received by the target volume and Organ at risk, as well as the results of the isodose curve. The research design used was Cross-Sectional and qualitative analysis. Data was obtained from simulation results in the Treatment Planning System (TPS) as a Dose Volume Histogram (DVH) by conducting Literature Studies, Observations, Documentation, and FGD Techniques. This research will be conducted in July 2023 at the Radiation Oncology Installation of Siloam MRCCC Hospital Semanggi. A study was conducted on 11 patients with brain tumors who received radiation therapy with IMRT or VMAT techniques. The results of this study showed no significant difference in dose received by the target volume and dose of Organ at risk in both techniques in statistical tests, but based on the average results descriptively showed that the VMAT technique was better than the IMRT technique. This is indicated by the dose received by the target volume according to the plan.