Acute Respiratory Infection (ARI) is an acute infection of the respiratory tract caused by microorganisms in the respiratory tract. ARI is often encountered and is the leading cause of death in infants. Immunization is one of the efforts that can reduce the risk of ARI. To determine the relationship between immunization status and the incidence of ARI in infants in the Gunungsari Cirebon Health Center area. This study was an observational study with a cross-sectional design. The sample size was 99, using a consecutive sampling technique. Statistical tests used the Chi-square test. Data collection used medical records to see the diagnosis of ARI and the KMS book to see the immunization status. A total of (57.6%) of the 99 infants were diagnosed with ARI, and (82.8%) of the infants had completed basic ARI immunization. The results of the Chi-square test showed a p-value of 0.083. There is no relationship between immunization status and the incidence of ARI in infants in the Gunungsari Cirebon Health Center area, however, immunization can prevent most deadly influenza-related diseases, which is a strong predictor of death in infants.